OPAP LECTURES ONLINE: "Sleep Loss Impairs Glucose Tolerance in a Mouse Model"

Join us on July 15, 2020 at 8PM for a short lecture on an experimental sleep study entitled:

"Sleep loss impairs glucose tolerance in a mouse model"
by 
Professor Sachiko Chikahisa
Department of Integrative Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima Japan

Abstract: Sleep loss is known to be associated with a variety of metabolic diseases including diabetes. However, the molecular mechanisms underlying the interaction between sleep loss and metabolic impairment are still unclear. In the present study, we investigated whether chronic sleep disturbance by placed on wire net would induce diabetes in mice. Mice reared on wire net for 2 weeks demonstrated decreased amount of non-rapid eye movement (NREM) sleep, attenuated sleep depth, and increased sleep fragmentation, compared with that of control group reared on normal sawdust. These sleep-disrupted mice showed impaired glucose tolerance test. One-week treatment with a sleep-inducing agent (histamine H1 receptor antagonist) ameliorated the glucose intolerance and improved sleep quality in mice reared on wire net. Mice reared on wire showed an increased number of mast cells in both the brain and adipose tissue. Deletion of mast cells ameliorated the impairment of glucose tolerance in these mice.  Our data indicates that sleep quality is important for the maintenance of metabolic function, and these may lead to new mechanisms for chronic sleep disturbance and glucose homeostasis abnormalities.

When: July 15, 2020 8PM MNL Time

Where: Via FB Live on OPAP LECTURES ONLINE FB page

https://www.facebook.com/groups/217869892601722/

REGISTER HERE:

https://facebook.com/events/s/dental-sleep-medicine-lectures/397545661204339/?ti=cl